A Novel Gut-Eye Connection Explored in Uveitis

Article: Pathway to better eye health runs through the gut
Source: Oregon Health & Sciences University
Published: December 21, 2021 

About 70% of the human immune system is found in our gastrointestinal tract, where it interacts with the gut microbiome. Scientists are beginning to investigate how this ecosystem of gut microorganisms interact with our immune system in the context of eye health, for example, in inflammatory eye diseases such as noninfectious (chronic) uveitis. This novel angle has produced convincing data in animal models. For example, experiments in mice revealed that severity of inflammation from uveitis is partially related to a reduction of regulatory T cells (Tregs) in the gut, which normally function to prevent inflammation. Furthermore, interventions such as giving these mice organic compounds called short-chain fatty acids or oral antibiotics increased the number of Tregs in the gut and improved intestinal permeability and structure, all of which led to decreased eye inflammation. With funding from several awards and grants from the National Institutes of Health, these researchers next plan to dig deeper into the mechanisms that gut microbes use to protect the eye from inflammatory diseases and lay the foundation for new, targeted medications for uveitis. Motivated by the patients she cares for, the lead researcher of this project states, "We’ve hit on something really novel that has the potential to make a difference for people living with uveitis."

My rating of this study: ⭐⭐⭐

Lin P. "Intestinal T cells and microbiota as therapeutic targets in autoimmune uveitis."
NIH RePORTER. 1R01EY032882-01